Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging

Wei Hung Liu, Yang Kao Wang, Chi Chang Wu, Win Pin Deng, Kuang Hsun Lin, Wen Cheng Lo, Ching Li Tseng

研究成果: Article

摘要

X-ray computed tomography (CT) is one of the most powerful non-invasive diagnostic techniques nowadays. The iodinated molecules used as CT contrast agents in the clinic have short circulation times in the body, which significantly restrict its applications. Furthermore, some patients are hypersensitive to iodine. So, researchers have made tremendous efforts to improve the property of iodine. Besides, cis-diammineplatinum (II) dichloride (cisplatin), a major chemo agent for cancer treatment, possess higher X-ray attenuation coefficient being a CT contrast agent. The incorporation of cisplatin with an iodinated agent could facilitate the quality of CT images and damage cancer cells simultaneously. To reduce toxicity of a contrast agent, polymer matrix, gelatin, was incorporated for avoiding contact with nontarget cells. In this study, we combined the iodine contrast agent, 1,3-N-bis (2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4, 6-triiodobenzene-1,3-dicarboxamide (iohexol), with cisplatin, and then examined them in a micro CT with different X-ray tube voltages (50 kV, 80 kV, 100 kV) to find optimal scanning conditions for imaging. As expected, iohexol combined with cisplatin enhanced X-ray attenuation and image contrast. The optimal CT image could be acquired at iohexol and cisplatin concentrations of 50 mg/ml and 3 mg/ml, respectively, under 80 kV irradiation. Finally, the iohexol-cisplatin- gelatin solution was then fabricated into nanoparticles of sizes about 240 nm, which may suitable for in vivo delivery.

原文English
頁(從 - 到)267-271
頁數5
期刊Journal of Polymer Engineering
34
發行號3
DOIs
出版狀態Published - 2014 五月 1

指紋

Iohexol
Gelatin
Cisplatin
Tomography
Imaging techniques
Contrast Media
Iodine
X rays
X ray tubes
Oncology
Polymer matrix
Toxicity
Cells
Irradiation
Nanoparticles
Scanning
Molecules
Electric potential

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

引用此文

Liu, Wei Hung ; Wang, Yang Kao ; Wu, Chi Chang ; Deng, Win Pin ; Lin, Kuang Hsun ; Lo, Wen Cheng ; Tseng, Ching Li. / Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging. 於: Journal of Polymer Engineering. 2014 ; 卷 34, 編號 3. 頁 267-271.
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Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging. / Liu, Wei Hung; Wang, Yang Kao; Wu, Chi Chang; Deng, Win Pin; Lin, Kuang Hsun; Lo, Wen Cheng; Tseng, Ching Li.

於: Journal of Polymer Engineering, 卷 34, 編號 3, 01.05.2014, p. 267-271.

研究成果: Article

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AU - Wang, Yang Kao

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AU - Deng, Win Pin

AU - Lin, Kuang Hsun

AU - Lo, Wen Cheng

AU - Tseng, Ching Li

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AB - X-ray computed tomography (CT) is one of the most powerful non-invasive diagnostic techniques nowadays. The iodinated molecules used as CT contrast agents in the clinic have short circulation times in the body, which significantly restrict its applications. Furthermore, some patients are hypersensitive to iodine. So, researchers have made tremendous efforts to improve the property of iodine. Besides, cis-diammineplatinum (II) dichloride (cisplatin), a major chemo agent for cancer treatment, possess higher X-ray attenuation coefficient being a CT contrast agent. The incorporation of cisplatin with an iodinated agent could facilitate the quality of CT images and damage cancer cells simultaneously. To reduce toxicity of a contrast agent, polymer matrix, gelatin, was incorporated for avoiding contact with nontarget cells. In this study, we combined the iodine contrast agent, 1,3-N-bis (2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4, 6-triiodobenzene-1,3-dicarboxamide (iohexol), with cisplatin, and then examined them in a micro CT with different X-ray tube voltages (50 kV, 80 kV, 100 kV) to find optimal scanning conditions for imaging. As expected, iohexol combined with cisplatin enhanced X-ray attenuation and image contrast. The optimal CT image could be acquired at iohexol and cisplatin concentrations of 50 mg/ml and 3 mg/ml, respectively, under 80 kV irradiation. Finally, the iohexol-cisplatin- gelatin solution was then fabricated into nanoparticles of sizes about 240 nm, which may suitable for in vivo delivery.

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