Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system

Yaowalak Boonsongrit, Hiroya Abe, Kazuyoshi Sato, Makio Naito, Masahiro Yoshimura, Hideki Ichikawa, Yoshinobu Fukumori

研究成果: Article同行評審

67 引文 斯高帕斯(Scopus)

摘要

Desorption behavior of a model protein (bovine serum albumin, BSA) on commercial hydroxyapatite (HAp) microspheres and its control were investigated for protein delivery system. The desorption behavior related strongly to the phosphate concentration in phosphate buffer solution: the amount of desorbed BSA increased when the phosphate concentration increased. In physiological buffer solution, which contains 10 mM phosphate, the initial burst release of BSA was observed: 70% of BSA was rapidly desorbed after 0.5 h, and 80% after 24 h. In contrast, the extremely low release profile of BSA was observed in distilled water. For the controlled release of BSA in physiological condition, the BSA-loaded HAp microspheres were encapsulated with a biodegradable polymer, poly(lactic acid-co-glycolic acid) (PLGA) by a solid-in oil-in water (S/O/W) emulsion solvent evaporation method. The initial burst was significantly reduced, and the BSA release was remarkably prolonged by the encapsulation.

原文English
頁(從 - 到)162-165
頁數4
期刊Materials Science and Engineering B: Solid-State Materials for Advanced Technology
148
發行號1-3
DOIs
出版狀態Published - 2008 二月 25

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)
  • 凝聚態物理學
  • 材料力學
  • 機械工業

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