Conversion of azides into diazo compounds in water

Ho-Hsuan Chou, Ronald T. Raines

研究成果: Article

24 引文 斯高帕斯(Scopus)

摘要

Diazo compounds are in widespread use in synthetic organic chemistry but have untapped potential in chemical biology. We report on the design and optimization of a phosphinoester that mediates the efficient conversion of azides into diazo compounds in phosphate buffer at neutral pH and room temperature. High yields are maintained in the presence of common nucleophilic or electrophilic functional groups, and reaction progress can be monitored by colorimetry. As azido groups are easy to install and maintain in biopolymers or their ligands, this new mode of azide reactivity could have substantial utility in chemical biology.

原文English
頁(從 - 到)14936-14939
頁數4
期刊Journal of the American Chemical Society
135
發行號40
DOIs
出版狀態Published - 2013 十月 21

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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