Copper-Catalyzed Decarboxylative Difluoromethylation

Xiaojun Zeng, Wenhao Yan, Samson B. Zacate, Tzu Hsuan Chao, Xiaodong Sun, Zhi Cao, Kate G.E. Bradford, Matthew Paeth, Sam B. Tyndall, Kundi Yang, Tung Chun Kuo, Mu Jeng Cheng, Wei Liu

研究成果: Article

15 引文 斯高帕斯(Scopus)


We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals.

頁(從 - 到)11398-11403
期刊Journal of the American Chemical Society
出版狀態Published - 2019 七月 24

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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    Zeng, X., Yan, W., Zacate, S. B., Chao, T. H., Sun, X., Cao, Z., Bradford, K. G. E., Paeth, M., Tyndall, S. B., Yang, K., Kuo, T. C., Cheng, M. J., & Liu, W. (2019). Copper-Catalyzed Decarboxylative Difluoromethylation. Journal of the American Chemical Society, 141(29), 11398-11403.