Copper (I) Chloride-Catalyzed Photoredox Synthesis of Multifunctionalized Compounds at Room Temperature and Their Antifungal Activities

Vaibhav Pramod Charpe, Ayyakkannu Ragupathi, Arunachalam Sagadevan, Yeu Shiuan Ho, Mu Jeng Cheng, Kuo Chu Hwang

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

A simple visible-light-induced CuCl-catalyzed synthesis was developed for highly functionalized carbon-centered compounds (α-alk/aryloxy-α-diaryl/alkylaryl-acetaldehydes/ketones) at room temperature using benzoquinone, alkyl/aryl alcohol, and alkyl/aryl terminal/internal alkynes. Late-stage functionalized compounds show good antifungal activities, especially against Candida krusei fungal strain, in in vitro experiments (the Broth microdilution method). Moreover, toxicity tests (zebrafish egg model experiments) indicated that these compounds had negligible cytotoxicity. The green chemistry metrics (E-factor value is 7.3) and eco-scale (eco-scale value is 58.8) evaluations show that the method is simple, mild, highly efficient, eco-friendly, and environmentally feasible.

原文English
文章編號e202300110
期刊Chemistry - A European Journal
29
發行號22
DOIs
出版狀態Published - 2023 4月 18

All Science Journal Classification (ASJC) codes

  • 一般化學
  • 催化
  • 有機化學

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