Copper-Mediated Trifluoromethylation of Benzylic Csp3−H Bonds

Matthew Paeth, William Carson, Jheng Hua Luo, David Tierney, Zhi Cao, Mu Jeng Cheng, Wei Liu

研究成果: Article

33 引文 斯高帕斯(Scopus)


Trifluoromethyl-containing compounds play a significant role in medicinal chemistry, materials and fine chemistry. Although direct C−H trifluoromethylation has been achieved on Csp2−H bonds, direct conversion of Csp3−H bonds to Csp3−CF3 remains challenging. We report herein an efficient protocol for the selective trifluoromethylation of benzylic C−H bonds. This process is mediated by a combination CuIII−CF3 species and persulfate salts. A wide range of methylarenes can be selectively trifluoromethylated at the benzylic positions. A combination of experimental and theoretical mechanistic studies suggests that the reaction involves a radical intermediate and a CuIII−CF3 species as the CF3 transfer reagent.

頁(從 - 到)11559-11563
期刊Chemistry - A European Journal
出版狀態Published - 2018 八月 9

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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