Copper sulfide nanodisk as photoacoustic contrast agent for ovarian tumor detection

Junxin Wang, Su Wen Hsu, Andrea R. Tao, Jesse V. Jokerst

研究成果: Conference contribution

摘要

Ultrasound is broadly used in the clinics yet is limited in early cancer detection because of its poor contrast between healthy and diseased tissues. Photoacoustic imaging can improve this limitation and has been extensively studied in pre-clinical models. Contrast agents can help improve the accuracy of diagnosis. We recently reported a novel copper sulfide (CuS) nanodisk with strong directionally-localized surface plasmon resonance in the near infrared region. This plasmonic resonance of nanodisks is tunable by changing the size and aspect ratio of CuS nanodisk. Here, we demonstrate this CuS nanodisk is a strong photoacoustic contrast agent. We prepared CuS nanodisks via a solvent-based synthesis followed by surface modification of poly(ethylene glycol) methyl ether thiol for in vivo applications. These CuS nanodisks can be detected at a concentration as low as 26 pM at 920 nm. Their nanosize and strong photoacoustic response make this novel CuS nanodisk a strong candidate for photoacoustic cancer imaging.

原文English
主出版物標題Photons Plus Ultrasound
主出版物子標題Imaging and Sensing 2017
編輯Alexander A. Oraevsky, Lihong V. Wang
發行者SPIE
ISBN(電子)9781510605695
DOIs
出版狀態Published - 2017 一月 1
事件Photons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
持續時間: 2017 一月 292017 二月 1

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10064
ISSN(列印)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2017
國家/地區United States
城市San Francisco
期間17-01-2917-02-01

All Science Journal Classification (ASJC) codes

  • 電子、光磁材料
  • 生物材料
  • 原子與分子物理與光學
  • 放射學、核子醫學和影像學

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