Coral Hydrate, a Novel Antioxidant, Improves Alcohol Intoxication in Mice

研究成果: Article同行評審

摘要

Alcohol-drinking culture may cause individuals to periodically experience unpleasant hangovers. In addition, ethanol catabolism stimulates the production of free radicals that may cause liver injury and further lead to the development of chronic alcoholic fatty liver disease. Although a number of studies have suggested that hydrogenated water may be consumed to act as free radical scavenger, its instability limits its application. In this study, we used coral hydrate (i.e., hydrogenated coral materials) as a more stable hydrogen source and evaluated its effects in a murine model of alcohol intoxication. In solution, coral hydrate exhibited much more stable redox potential than did hydrogenated water. Furthermore, administration of coral hydrate by oral gavage significantly pro-longed the time to fall asleep and decreased the total sleep time in mice that received intraperitoneal injection of ethanol. The mice receiving coral hydrate also had lower plasma ethanol and acetalde-hyde levels than controls. In line with this observation, hepatic expression of alcohol dehydrogenase, acetaldehyde dehydrogenase, catalase and glutathione peroxidase were all significantly increased by the treatment. Meanwhile, alcohol-induced upregulation of pro-inflammatory factors was attenuated by the administration of coral hydrate. Taken together, our data suggest that coral hydrate might be an effective novel treatment for alcohol intoxication.

原文English
文章編號1290
期刊Antioxidants
11
發行號7
DOIs
出版狀態Published - 2022 7月

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 生理學
  • 生物化學
  • 分子生物學
  • 臨床生物化學
  • 細胞生物學

指紋

深入研究「Coral Hydrate, a Novel Antioxidant, Improves Alcohol Intoxication in Mice」主題。共同形成了獨特的指紋。

引用此