Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Hsien Jen Cheng, Yueh Hsia Luo, Shu Wen Wan, Chiou Feng Lin, Shan-Tair Wang, Nguyen Thanh Hung, Ching Chuan Liu, Tzong Shiann Ho, Hsiao-Sheng Liu, Trai Ming Yeh, Yee-Shin Lin

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

We have previously shown that anti-dengue virus nonstructural protein 1 (anti-DENV NS1) antibodies cross-react with endothelial cells, and several autoantigens have been identified. This study shows that the antibody levels against these self-proteins are higher in sera from patients with dengue hemorrhagic fever (DHF) than those in control sera. Anti-protein disulfide isomerase (PDI) and anti-heat shock protein 60 (anti-HSP60) IgM levels correlated with both anti-endothelial cells and anti-DENV NS1 IgM titers. A cross-reactive epitope on the NS1 amino acid residues 311-330 (P311-330) had been predicted. We further found that there were higher IgM and IgG levels against P311-330 in DHF patients' sera than those in the control sera. In addition, correlations were observed between anti-PDI with anti-P311-330 IgM and IgG levels, respectively. Therefore, our results indicate that DENV NS1 P311-330 is a major epitope for cross-reactive antibodies to PDI on the endothelial cell surface, which may play an important role in DENV infection-induced autoimmunity.

原文English
頁(從 - 到)989-995
頁數7
期刊American Journal of Tropical Medicine and Hygiene
92
發行號5
DOIs
出版狀態Published - 2015 5月 1

All Science Journal Classification (ASJC) codes

  • 寄生物學
  • 病毒學
  • 傳染性疾病

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