C18 dibenzocyclooctadiene lignans from Kadsura philippinensis

Ya Ching Shen, Chia Ching Liaw, Yuan Bin Cheng, Atallah F. Ahmed, Mei Chou Lai, Shorong Shii Liou, Tian Shung Wu, Yao Haur Kuo, Yu Chi Lin

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

Four new C18 dibenzocyclooctadiene lignans, kadsuphilins A (1) and B (3), 6-epi-gomisin (2), and 1-demethylkadsuphilin A (4), along with eight known related metabolites, were isolated from an EtOAc fraction of an alcoholic extract of the aerial parts of Kadsura philippinensis growing in Taiwan. The structures of 1-4 were elucidated on the basis of spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments, and by comparison of their spectroscopic data with those of related metabolites. The configurations of the biphenyl and cyclooctadiene moieties were deduced from circular dichroism (CD) and NOESY NMR spectra, respectively. Some of the compounds showed radical-scavenging activity in a DPPH-HPLC method.

原文English
頁(從 - 到)963-966
頁數4
期刊Journal of Natural Products
69
發行號6
DOIs
出版狀態Published - 2006 六月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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