Current progress in antivascular tumor therapy

Yi Ju Ho, Tzu Chia Wang, Ching Hsiang Fan, Chih Kuang Yeh

研究成果: Review article同行評審

14 引文 斯高帕斯(Scopus)

摘要

The tumor vasculature transports oxygen, nutrients and drugs for crucial roles in tumor therapy. Antivascular therapy directly targets existing tumor vessels to reduce blood perfusion and then inhibit tumor growth. Vascular disrupting agents and ultrasound-stimulated microbubble destruction use chemical toxicity and physical effect, respectively, to damage vascular endothelial cells for antivascular therapy. Moreover, antivascular therapy can break vessel wall barriers and change the tumor microenvironment to compensate for the limitations of conventional chemotherapy or radiotherapy. This review presents current progress and an overview of antivascular therapy, which can inform the development and application in cancer research. This review presents current progress and an overview of antivascular therapy to inform its development and application in cancer research.

原文English
頁(從 - 到)1503-1515
頁數13
期刊Drug Discovery Today
22
發行號10
DOIs
出版狀態Published - 2017 十月

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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