Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs

Shashwat S. Banerjee, Dong Hwang Chen

研究成果: Article同行評審

33 引文 斯高帕斯(Scopus)

摘要

A magnetic nanosystem that simultaneously implements the cyclodextrin-drug complexation power, bioadhesive property of gum arabic (GA) and inherent magnetic properties of Fe3O4 nanoparticles, has recently been reported. In this study, a magnetic nanocarrier was fabricated by conjugating 2-hydroxypropyl-cyclodextrin (HCD) onto the gum arabic modified magnetic nanoparticles (GAMNP). The analyses of transmission electron microscopy (TEM) and dynamic light scattering (DLS) revealed that the product had a mean diameter of 14.8 nm and a mean hydrodynamic diameter of 29.3 nm. This nanocarrier showed good loading efficiency for ketoprofen. In addition, the in vitro release profile of ketoprofen from HCD-GAMNP was characterized by an initial fast release followed by a delayed release phase. In view of the better biocompatibility and the combined properties like specific targeting, complexation ability with hydrophobic drugs makes the nanosystem an exciting prospect for drug delivery.

原文English
頁(從 - 到)2071-2078
頁數8
期刊Journal of Nanoparticle Research
11
發行號8
DOIs
出版狀態Published - 2009 11月

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 一般化學
  • 原子與分子物理與光學
  • 建模與模擬
  • 一般材料科學
  • 凝聚態物理學

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