Cyclooxygenase-2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

The development of colorectal cancer (CRC) is commonly accompanied by the overexpression of the cyclooxygenase-2 (COX-2) gene, with high levels being most common in early colorectal lesions. In the present study, we hypothesized that the expression of COX-2 in normal mucosa affects the expression of COX-2 in adjacent tumors. COX-2 protein expression levels were determined in tumor tissues and the adjacent normal mucosa of 49 paired clinical CRC specimens using western blotting and immunohistochemistry (IHC) staining. The majority of specimens exhibited an extremely low level of COX-2 expression in the tumor tissue and a markedly higher expression level in the adjacent normal tissue, however, high COX-2 expression in the tumor was shown to correlate with a high recurrence rate and poor overall survival. Of the nine CRC cell lines, HT29 showed consistently higher levels of COX-2 expression. Therefore, COX-2 expression in the normal tissue adjacent to the tumor may be involved in the tumorigenesis of CRC. These observations are likely to be useful in determining the significance of COX-2 expression in the tumorigenesis of CRC.

原文English
頁(從 - 到)733-739
頁數7
期刊Oncology Letters
6
發行號3
DOIs
出版狀態Published - 2013 九月 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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