Cyclophilin A is Associated with Peripheral Artery Disease and Chronic Kidney Disease in Geriatrics: The Tianliao Old People (TOP) Study

Meng Chuan Liu, Yen Wei Lee, Po Tseng Lee, Chin Sung Chang, Yun Lin Tai, Jia Rong Yu, Xiao Ting Su, Ling Wei Hsu, Sheng Hsiang Lin, Chi Hsing Wu, Ping Yen Liu

研究成果: Article

11 引文 (Scopus)

摘要

Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population and its association with CyPA and renal function. Residents of Tianliao District, a rural community in southern Taiwan, were surveyed. An ankle-brachial index (ABI) < 0.91 was defined as PAOD. Chronic kidney disease (CKD) was defined based on eGFR levels < 60 mL/min/1.73m 2. Serum CyPA was measured. Of the 473 participants, 68 (14.4%) had PAOD. Multiple logistic regression analysis showed PAOD was significantly associated with lower eGFR, lower BMI, higher glycated hemoglobin and higher pulse pressure. Serum CyPA levels in participants with PAOD were significantly higher than those with normal ABI values (47.3 ± 0.4 vs. 25.5 ± 0.2 ng/mL, p < 0.001). Moreover, eGFR inversely correlated with serum CyPA level (p < 0.05) in participants with CKD, but not in participants with normal renal function. In conclusion, with a prevalence of PAOD as high as 14.4% in an elderly community, CyPA might be the link between PAOD and advanced impaired renal function.

原文English
文章編號9937
期刊Scientific reports
5
DOIs
出版狀態Published - 2015 四月 24

指紋

Cyclophilin A
Peripheral Arterial Disease
Chronic Renal Insufficiency
Geriatrics
Ankle Brachial Index
Taiwan
Kidney
Serum
Glycosylated Hemoglobin A
Rural Population
Vascular Smooth Muscle
Smooth Muscle Myocytes
Oxidative Stress
Logistic Models
Regression Analysis
Blood Pressure

All Science Journal Classification (ASJC) codes

  • General

引用此文

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title = "Cyclophilin A is Associated with Peripheral Artery Disease and Chronic Kidney Disease in Geriatrics: The Tianliao Old People (TOP) Study",
abstract = "Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population and its association with CyPA and renal function. Residents of Tianliao District, a rural community in southern Taiwan, were surveyed. An ankle-brachial index (ABI) < 0.91 was defined as PAOD. Chronic kidney disease (CKD) was defined based on eGFR levels < 60 mL/min/1.73m 2. Serum CyPA was measured. Of the 473 participants, 68 (14.4{\%}) had PAOD. Multiple logistic regression analysis showed PAOD was significantly associated with lower eGFR, lower BMI, higher glycated hemoglobin and higher pulse pressure. Serum CyPA levels in participants with PAOD were significantly higher than those with normal ABI values (47.3 ± 0.4 vs. 25.5 ± 0.2 ng/mL, p < 0.001). Moreover, eGFR inversely correlated with serum CyPA level (p < 0.05) in participants with CKD, but not in participants with normal renal function. In conclusion, with a prevalence of PAOD as high as 14.4{\%} in an elderly community, CyPA might be the link between PAOD and advanced impaired renal function.",
author = "Liu, {Meng Chuan} and Lee, {Yen Wei} and Lee, {Po Tseng} and Chang, {Chin Sung} and Tai, {Yun Lin} and Yu, {Jia Rong} and Su, {Xiao Ting} and Hsu, {Ling Wei} and Lin, {Sheng Hsiang} and Wu, {Chi Hsing} and Liu, {Ping Yen}",
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T1 - Cyclophilin A is Associated with Peripheral Artery Disease and Chronic Kidney Disease in Geriatrics

T2 - The Tianliao Old People (TOP) Study

AU - Liu, Meng Chuan

AU - Lee, Yen Wei

AU - Lee, Po Tseng

AU - Chang, Chin Sung

AU - Tai, Yun Lin

AU - Yu, Jia Rong

AU - Su, Xiao Ting

AU - Hsu, Ling Wei

AU - Lin, Sheng Hsiang

AU - Wu, Chi Hsing

AU - Liu, Ping Yen

PY - 2015/4/24

Y1 - 2015/4/24

N2 - Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population and its association with CyPA and renal function. Residents of Tianliao District, a rural community in southern Taiwan, were surveyed. An ankle-brachial index (ABI) < 0.91 was defined as PAOD. Chronic kidney disease (CKD) was defined based on eGFR levels < 60 mL/min/1.73m 2. Serum CyPA was measured. Of the 473 participants, 68 (14.4%) had PAOD. Multiple logistic regression analysis showed PAOD was significantly associated with lower eGFR, lower BMI, higher glycated hemoglobin and higher pulse pressure. Serum CyPA levels in participants with PAOD were significantly higher than those with normal ABI values (47.3 ± 0.4 vs. 25.5 ± 0.2 ng/mL, p < 0.001). Moreover, eGFR inversely correlated with serum CyPA level (p < 0.05) in participants with CKD, but not in participants with normal renal function. In conclusion, with a prevalence of PAOD as high as 14.4% in an elderly community, CyPA might be the link between PAOD and advanced impaired renal function.

AB - Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population and its association with CyPA and renal function. Residents of Tianliao District, a rural community in southern Taiwan, were surveyed. An ankle-brachial index (ABI) < 0.91 was defined as PAOD. Chronic kidney disease (CKD) was defined based on eGFR levels < 60 mL/min/1.73m 2. Serum CyPA was measured. Of the 473 participants, 68 (14.4%) had PAOD. Multiple logistic regression analysis showed PAOD was significantly associated with lower eGFR, lower BMI, higher glycated hemoglobin and higher pulse pressure. Serum CyPA levels in participants with PAOD were significantly higher than those with normal ABI values (47.3 ± 0.4 vs. 25.5 ± 0.2 ng/mL, p < 0.001). Moreover, eGFR inversely correlated with serum CyPA level (p < 0.05) in participants with CKD, but not in participants with normal renal function. In conclusion, with a prevalence of PAOD as high as 14.4% in an elderly community, CyPA might be the link between PAOD and advanced impaired renal function.

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