Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis

研究成果: Review article

72 引文 (Scopus)

摘要

Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot, and mouth disease. It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death. EV71 replicates in leukocytes, endothelial cells, and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. Cytokines and chemokines play an important role in the pathogenesis EV71 brain stem encephalitis. Both the CNS and the systemic inflammatory responses to infection play important, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. Administration of intravenous immunoglobulin and milrinone, a phosphodiesterase inhibitor, has been shown to modulate inflammation, to reduce sympathetic overactivity, and to improve survival in patients with EV71 autonomic nervous system dysregulation and pulmonary edema.

原文English
文章編號876241
期刊Clinical and Developmental Immunology
2012
DOIs
出版狀態Published - 2012 九月 17

指紋

Enterovirus
Encephalitis
Brain Stem
Cytokines
Pulmonary Edema
Innate Immunity
Herpangina
Central Nervous System
Hand, Foot and Mouth Disease
Milrinone
Phosphodiesterase Inhibitors
Intravenous Immunoglobulins
Autonomic Nervous System
Chemokines
Dendritic Cells
Antiviral Agents
Leukocytes
Endothelial Cells
Inflammation
Survival

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

引用此文

@article{e49de5dc2a2d4550b7dbe29309a0b8cc,
title = "Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis",
abstract = "Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot, and mouth disease. It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death. EV71 replicates in leukocytes, endothelial cells, and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. Cytokines and chemokines play an important role in the pathogenesis EV71 brain stem encephalitis. Both the CNS and the systemic inflammatory responses to infection play important, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. Administration of intravenous immunoglobulin and milrinone, a phosphodiesterase inhibitor, has been shown to modulate inflammation, to reduce sympathetic overactivity, and to improve survival in patients with EV71 autonomic nervous system dysregulation and pulmonary edema.",
author = "Wang, {Shih Min} and Lei, {Huan Yao} and Liu, {Ching Chuan}",
year = "2012",
month = "9",
day = "17",
doi = "10.1155/2012/876241",
language = "English",
volume = "2012",
journal = "Journal of Immunology Research",
issn = "2314-8861",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis

AU - Wang, Shih Min

AU - Lei, Huan Yao

AU - Liu, Ching Chuan

PY - 2012/9/17

Y1 - 2012/9/17

N2 - Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot, and mouth disease. It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death. EV71 replicates in leukocytes, endothelial cells, and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. Cytokines and chemokines play an important role in the pathogenesis EV71 brain stem encephalitis. Both the CNS and the systemic inflammatory responses to infection play important, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. Administration of intravenous immunoglobulin and milrinone, a phosphodiesterase inhibitor, has been shown to modulate inflammation, to reduce sympathetic overactivity, and to improve survival in patients with EV71 autonomic nervous system dysregulation and pulmonary edema.

AB - Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot, and mouth disease. It can also cause severe complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severe complication that can lead to death. EV71 replicates in leukocytes, endothelial cells, and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. Cytokines and chemokines play an important role in the pathogenesis EV71 brain stem encephalitis. Both the CNS and the systemic inflammatory responses to infection play important, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. Administration of intravenous immunoglobulin and milrinone, a phosphodiesterase inhibitor, has been shown to modulate inflammation, to reduce sympathetic overactivity, and to improve survival in patients with EV71 autonomic nervous system dysregulation and pulmonary edema.

UR - http://www.scopus.com/inward/record.url?scp=84866128081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866128081&partnerID=8YFLogxK

U2 - 10.1155/2012/876241

DO - 10.1155/2012/876241

M3 - Review article

C2 - 22956971

AN - SCOPUS:84866128081

VL - 2012

JO - Journal of Immunology Research

JF - Journal of Immunology Research

SN - 2314-8861

M1 - 876241

ER -