Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

Ping Chung Kuo, Li Shian Shi, Amooru G. Damu, Chung Ren Su, Chieh Hung Huang, Chih Huang Ke, Jin Bin Wu, Ai Jeng Lin, Kenneth F. Bastow, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

143 引文 斯高帕斯(Scopus)

摘要

Three new [n-pentyl β-carboline-l-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known β-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

原文English
頁(從 - 到)1324-1327
頁數4
期刊Journal of Natural Products
66
發行號10
DOIs
出版狀態Published - 2003 十月

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

指紋

深入研究「Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia」主題。共同形成了獨特的指紋。

引用此