Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia

Ping Chung Kuo, Amooru G. Damu, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

130 引文 斯高帕斯(Scopus)

摘要

Sixty-five compounds were isolated from the roots of Eurycoma longifolia and characterized by comprehensive analyses of their 1D and 2D NMR, and mass spectral data. Among these isolates, four quassinoid diterpenoids were reported from natural sources for the first time, namely eurycomalide A (1), eurycomalide B (2), 13β, 21-dihydroxyeurycomanol (3), and 5α, 14β, 15β-trihydroxyklaineanone (4). Screening of cytotoxicity, anti-HIV and antimalarial activity of these isolated compounds was also furnished by in vitro assays. Compounds 12, 13, 17, 18, 36, 38, 59, and 62 demonstrated strong cytotoxicity toward human lung cancer (A-549) cell lines, however, 12, 13, 17, 38, 57, 58, and 59 exhibited strong cytoxicity toward human breast cancer (MCF-7) cell lines. Compounds 57 and 58 displayed potent antimalarial activity against the resistant Plasmodium falciparum. The thorough studies on the stereochemistry of the different quassinoid diterpenoids provide a clear reference to the scientists who are interested on this field.

原文English
頁(從 - 到)537-544
頁數8
期刊Bioorganic and Medicinal Chemistry
12
發行號3
DOIs
出版狀態Published - 2004 二月 1

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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