Cytotoxic and antiplatelet aggregation principles of Ruta graveolens

Tian Shung Wu, Li Shian Shi, Jhi Joung Wang, Song Chou Iou, Hsien Chang Chang, Yuh Pan Chen, Yao Haur Kuo, Ya Ling Chang, Che Ming Teng

研究成果: Article同行評審

60 引文 斯高帕斯(Scopus)


Nineteen compounds have been isolated from the methanol extract of the root and aerial parts of Ruta graveolens. The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine (5), skimmianine (7), psoralen (8), chalepensin (12), clausindin (13), and graveolinine (16) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen. Arborinine (2), dictamine (5), isopimpinellin (11), clausindin (13), and graveoline (17) exhibited cytotoxic activity against KB, Hela, DLD, NCI and Hepa tumor cell lines.

頁(從 - 到)171-178
期刊Journal of the Chinese Chemical Society
出版狀態Published - 2003

All Science Journal Classification (ASJC) codes

  • 化學 (全部)


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