Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Cheng Chi Chen, Jyh Horng Wu, Ning Sun Yang, Jang Yang Chang, Ching Chuan Kuo, Sheng Yang Wang, Yueh Hsiung Kuo

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

(Figure presented) A novel C35-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC50 value of 6.44 ± 2.23 μM.

原文English
頁(從 - 到)2786-2789
頁數4
期刊Organic Letters
12
發行號12
DOIs
出版狀態Published - 2010 六月 18

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 物理與理論化學
  • 有機化學

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