Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria

Li Shian Shi, Sheng Chu Kuo, Han Dong Sun, Susan L. Morris-Natschke, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

Eight new cardiac glycosides/aglycones (antiaritoxiosides A-G, 1-7, and antiarotoxinin B, 8), two new coumarins (anticarins A-B, 41-42), and two new flavanones (antiarones L-K, 43-44) were isolated from trunk bark of Antiaris toxicaria together with 53 known compounds. The new structures were established by extensive analysis of spectroscopic data. Compound 1 (10-carboxy and 3α-hydroxy) and compounds 3-6 (10-hydroxy) contain unique substituents that are rarely found in cardiac glycosides. The cytotoxic effects of isolated compounds against ten human cancer cell lines, KB, KB-VIN, A549, MCF-7, U-87-MG, PC-3, 1A9, CAKI-1, HCT-9 and S-KMEL-2, were tested using the sulforhodamine B assay. Five compounds (12, 16, 20, 22, and 31) showed significant cytotoxicity against all ten cancer cell lines, with notable potency at the ng/mL level against some cell lines, which merits further development as clinical trial candidates.

原文English
頁(從 - 到)1889-1898
頁數10
期刊Bioorganic and Medicinal Chemistry
22
發行號6
DOIs
出版狀態Published - 2014 三月 15

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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