Cytotoxic phenanthroindolizidine alkaloids from the roots of ficus septica

Amooru F. Damu, Ping-Chung Kuo, Li Shian Shi, Chia Ying Li, Chung Ren Su, Tian-Shung Wu

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids, including ten new ficuseptines E-N (1-10) and ten known compounds. The cytotoxic effects of some of the isolateswere tested on gastric adenocarcinoma (NUGC) and nasopharyngeal carcinoma (HONE-1) cell lines and the results demonstrated that, with the exception of dehydrotylophorine, all the tested compounds displayed pronounced cytotoxic activity with significant cell growth inhibitory effects. In addition, 13aR-antofine was found to be highly effective with ED50 values of < 0.1 μg/mL against L-1210, P-388, A- 549 and HCT-8 cell lines in another assay.

原文English
頁(從 - 到)1152-1156
頁數5
期刊Planta Medica
75
發行號10
DOIs
出版狀態Published - 2009 十一月 11

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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