Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis

Pei Lin Wu, Ta Hsien Chuang, Cai Xia He, Tian Shung Wu

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9-O-feruloyl-(-) -secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9μg/mL, respectively.

原文English
頁(從 - 到)2193-2197
頁數5
期刊Bioorganic and Medicinal Chemistry
12
發行號9
DOIs
出版狀態Published - 2004 五月 1

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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