d-2-amino-5-phosphonovaleate blocks induction of long-term depression of the NMDA receptor-mediated synaptic component in rat hippocampus

Po Wu Gean, Jju Home Lin

研究成果: Article同行評審

19 引文 斯高帕斯(Scopus)

摘要

The long-term depression (LTD) of pharmacologically isolated N-methyl-d-aspartate (NMDA) receptor-mediated excitatory postsynaptic potential (EPSPNMDA) was studied in an vitro slice preparation of rat hippocampus. Intracellular recordings were made from CA1 pyramidal cells in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 μM) and picrotoxin (50 μM) which block non-NMDA and GABAA receptors, respectively. Low frequency (1 Hz) synaptic stimulation caused a transient decrease in the amplitude of EPSPNMDA that usually restored to its control level within 15 min after the stimulation. However, pairing of low frequency synaptic stimulation with postsynaptic depolarization induced an LTD of EPSPNMDA. The EPSPNMDA LTD could be blocked by d-2-amino-5-phosphonovaleate (d-APV, 20 μM) suggesting that the induction of LTD requires an increase in postsynaptic Ca2+, at least in part, due to synaptic activation of NMDA receptors during concomitant postsynaptic depolarization.

原文English
頁(從 - 到)170-172
頁數3
期刊Neuroscience Letters
158
發行號2
DOIs
出版狀態Published - 1993 八月 20

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

指紋 深入研究「d-2-amino-5-phosphonovaleate blocks induction of long-term depression of the NMDA receptor-mediated synaptic component in rat hippocampus」主題。共同形成了獨特的指紋。

引用此