Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice

Chang Chi Hsieh, Wen Chang Lin, Miau Rong Lee, Shih Lan Hsu, Hsiao Sheng Liu, Shung Te Kao, Ming Tsuen Hsieh

研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)

摘要

Dang-Gui-Bu-Xai-Tang (DGBXT), which includes Radix Angelicae Sinensis and Radix Astragali Membranaceus, is a traditional Chinese medicine used to modulate the lymphocyte activity of cancer patients after chemotherapy and radiotherapy. In the present study, we examined the cytotoxicity of DGBXT on transformed cells and the immunomodulating effects of DGBXT in a tumor-bearing murine model. DGBXT markedly inhibited the growth of the EJ-Ha-ras transformed LZEJ and LZEJ-C2 cells lines. Oral administration of DGBXT for three weeks significantly prevented the tumor development in mice that injected with LZEJ-C2 cells subcutaneously. Moreover, DGBXT effectively increased the population of cytotoxic T lymphocytes (CTLs) and NK cells, and down-regulated activated T helper cells (CD4+/CD25+) in spleen and tumor-draining lymph nodes (TDLN). Furthermore, DGBXT stimulated the production of tumor necrosis factor-α in in vitro cultured splenocytes. These results might explain the antitumor effects of DGBXT.

原文English
頁(從 - 到)259-271
頁數13
期刊Immunopharmacology and Immunotoxicology
25
發行號2
DOIs
出版狀態Published - 2003

All Science Journal Classification (ASJC) codes

  • 免疫學和過敏
  • 免疫學
  • 毒理學
  • 藥理

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