Decreased dopamine transporter availability in male smokers - A dual isotope SPECT study

Yen Kuang Yang, Wei Jen Yao, Tzung Lieh Yeh, I. Hui Lee, Po See Chen, Ru Band Lu, Nan Tsing Chiu

研究成果: Article

55 引文 斯高帕斯(Scopus)


Introduction: Although the mesolimbic dopaminergic system has been shown to play a role in reinforcing tobacco smoking, results of imaging studies that examine the relationship between tobacco smoking and the central dopamine system remain discrepant. To delineate the role of tobacco addiction in central pre- and post-synaptic dopaminergic activities, we analyzed the central D2-family receptors, the dopamine transporters (DAT), and degrees of dependence in male smokers. Methods: Eleven male smokers and 11 healthy non-smokers were recruited. The striatal dopamine D2/D3 receptor availability was approximated using SPECT and [123I] IBZM while the DAT availability was approximated using SPECT and [99mTc] TRODAT-1. All of the smokers completed the Fagerström Test for Nicotine Dependence (FTND) and other related questionnaires. Results: A decrease in DAT availability in the striatum of male smokers is noted (p < 05). However, the striatal D2/D3 receptor availability in male smokers does not differ from that of non-smokers. Conclusions: These findings suggest that cigarette smoking may alter central dopamine functions in males, particularly at the pre-synaptic sites.

頁(從 - 到)274-279
期刊Progress in Neuro-Psychopharmacology and Biological Psychiatry
出版狀態Published - 2008 一月 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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