Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration

Ru Yi Chao, Chia Hui Cheng, Sheng Nan Wu, Pei Chun Chen

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

Intracellular protein trafficking is tightly regulated, and improper trafficking might be the fundamental provocateur for human diseases including neurodegeneration. In neurons, protein trafficking to and from the plasma membrane affects synaptic plasticity. Voltage-gated potassium channel 2.1 (Kv2.1) is a predominant delayed rectifier potassium (K + ) current, and electrical activity patterns of dopamine (DA) neurons within the substantia nigra are generated and modulated by the orchestrated function of different ion channels. The pathological hallmark of Parkinson's disease (PD) is the progressive loss of these DA neurons, resulting in the degeneration of striatal dopaminergic terminals. However, whether trafficking of Kv2.1 channels contributes to PD remains unclear. In this study, we demonstrated that MPTP/MPP + increases the surface expression of the Kv2.1 channel and causes nigrostriatal degeneration by using a subchronic MPTP mouse model. The inhibition of the Kv2.1 channel by using a specific blocker, guangxitoxin-1E, protected nigrostriatal projections against MPTP/MPP + insult and thus facilitated the recovery of motor coordination. These findings highlight the importance of trafficking of Kv2.1 channels in the pathogenesis of PD. (Figure presented.).

原文English
頁(從 - 到)483-497
頁數15
期刊Journal of Neurochemistry
144
發行號4
DOIs
出版狀態Published - 2018 二月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 細胞與分子神經科學

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