Delivery of drug-loaded microbubbles and disruption of blood-brain barrier by focused ultrasound in a xenograft rat glioma model

Chien Yu Ting, Ching Hsiang Fan, Hao Li Liu, Tzu Chen Yen, Kuo Chen Wei, Chih Kuang Yeh

研究成果: Conference contribution

2 引文 斯高帕斯(Scopus)

摘要

Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The blood-brain barrier (BBB) provides a major obstacle to chemotherapy since therapeutic doses cannot be achieved by traditional drug delivery without severe systemic cytotoxic effects. Recently, microbubble (MB)-enhanced focused ultrasound (FUS) was shown to temporally and locally disrupt the BBB thereby enhancing drug delivery into brain tumors. Here we propose the concept of smart, multifunctional MBs capable of facilitating FUS-induced BBB disruption while serving as drug carrying vehicles and protecting drugs from rapid degradation. The designed MBs had a high loading capacity (efficiency of 68.01 ± 4.35 %) for 1,3-bis(2-chloroethyl)-1- nitrosourea (BCNU). When combined with FUS (1-MHz), these BCNU-MBs facilitated local BBB disruption and simultaneously released BCNU at the target site, thus increasing local BCNU deposition. And accumulation of BCNU in the liver was reduced 5-fold due to the slow reticuloendothelial system uptake of BCNU-MBs. In tumor-bearing animals, BCNU-MBs with FUS controlled tumor progression (915.3 % to 39.6 %) and improved median survival (29 days to 32.5 days). This study provides a new approach for designing multifunctional MBs to facilitate FUS-mediated chemotherapy for brain tumor treatment.

原文English
主出版物標題2011 IEEE International Ultrasonics Symposium, IUS 2011
頁面1463-1466
頁數4
DOIs
出版狀態Published - 2011
事件2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
持續時間: 2011 十月 182011 十月 21

出版系列

名字IEEE International Ultrasonics Symposium, IUS
ISSN(列印)1948-5719
ISSN(電子)1948-5727

Other

Other2011 IEEE International Ultrasonics Symposium, IUS 2011
國家/地區United States
城市Orlando, FL
期間11-10-1811-10-21

All Science Journal Classification (ASJC) codes

  • 聲學與超音波

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