Derivation of cinnamon blocks leukocyte attachment by interacting with sialosides

Wei Ling Lin, Shih Yun Guu, Chan Chuan Tsai, Ekambaranellore Prakash, Mohan Viswaraman, Hsing Bao Chen, Chuan Fa Chang

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This study aims to evaluate the effect of the cinnamon-derived molecule IND02 on the adhesion of leukocytes to host cells. The anti-inflammatory ability of IND02, a pentameric procyanidin type A polyphenol polymer isolated from cinnamon alcohol extract, was examined. Pretreatment with IND02 significantly reduced the attachment of THP-1 cells or neutrophils to TNF-α-activated HUVECs or E-selectin/ICAM-1, respectively. IND02 also reduced the binding of E-, L- and P-selectins with sialosides. Furthermore, IND02 could agglutinate human red blood cells (RBC), and the agglutination could be disrupted by sialylated glycoprotein. Our findings demonstrate that IND02, a cinnamon-derived compound, can interact with sialosides and block the binding of selectins and leukocytes with sialic acids.

原文English
文章編號e0130389
期刊PloS one
10
發行號6
DOIs
出版狀態Published - 2015 六月 15

All Science Journal Classification (ASJC) codes

  • 多學科

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