Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents

Xiao Feng Wang, Xing Tao Tian, Emika Ohkoshi, Bingjie Qin, Yi Nan Liu, Pei Chi Wu, Mann Jen Hour, Hsin Yi Hung, Keduo Qian, Rong Huang, Kenneth F. Bastow, William P. Janzen, Jian Jin, Susan L. Morris-Natschke, Kuo Hsiung Lee, Lan Xie

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

Based on a shared structural core of diarylamine in several known anticancer drugs as well as a new cytotoxic hit 6-chloro-2-(4-cyanophenyl)amino- 3-nitropyridine (7), 30 diarylamines and diarylethers were designed, synthesized, and evaluated for cytotoxic activity against A549, KB, KB-vin, and DU145 human tumor cell lines (HTCL). Four new leads 11e, 12, 13a, and 13b were discovered with GI50 values ranging from 0.33 to 3.45 μM. Preliminary SAR results revealed that a diarylamine or diarylether could serve as an active structural core, meta-chloro and ortho-nitro groups on the A-ring (either pyridine or phenyl ring) were necessary and crucial for cytotoxic activity, and the para-substituents on the other phenyl ring (B-ring) were related to inhibitory selectivity for different tumor cells. In an investigation of potential biological targets of the new leads, high thoughput kinase screening discovered that new leads 11e, 12 and 13b especially inhibit Mer tyrosine kinase, a proto-oncogene associated with munerous tumor types, with IC50 values of 2.2-3.0 μM. Therefore, these findings provide a good starting point to optimize a new class of compounds as potential anticancer agents, particularly targeting Mer tyrosine kinase.

原文English
頁(從 - 到)6224-6228
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
22
發行號19
DOIs
出版狀態Published - 2012 十月 1

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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