Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Jung Chen Su; Yu Ting Huang; Chang Shi Chen; Hao Chieh Chiu; Chung Wai Shiau

doi:10.3390/molecules23010027

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Jung Chen Su, Yu Ting Huang, Chang Shi Chen, Hao Chieh Chiu, Chung Wai Shiau

生物化學暨分子生物學研究所

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

摘要

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.

原文	English
文章編號	27
期刊	Molecules
卷	23
發行號	1
DOIs	https://doi.org/10.3390/molecules23010027
出版狀態	Published - 2018

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules23010027

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引用此

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abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.",

author = "Su, {Jung Chen} and Huang, {Yu Ting} and Chen, {Chang Shi} and Chiu, {Hao Chieh} and Shiau, {Chung Wai}",

note = "Funding Information: Acknowledgments: This work was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 104-3113-B-076-001, MOST 104-2321-B-010-017, MOST105-2321-B-010-008, MOST105-2325-B-010-007, MOST 106-2321-B-010-005, MOST106-3011-B-010-001, MOST 106-2320-B-010-018) and the Ministry of Education, Aiming for the Top University Plan (106AC-P645, 106AC-P632, 105AC-P645, 104AC-P693).",

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AU - Shiau, Chung Wai

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