Design: Designing Studies for Dose Response

Weng K. Wong, Peter A. Lachenbruch

研究成果: Chapter

1 引文 斯高帕斯(Scopus)

摘要

'Dose response' refers to the regression of a response on a stimulus. We review a number of options for dose-response designs, and compare various designs which may be used in practice. We start with two group designs. Next, we introduce basic optimal approximate design theory for simple linear and quadratic regression illustrating different criteria of optimality and their effect on the allocation of the levels of the dose. Then we obtain the efficiencies of these optimal approximate designs and some simple designs which have intuitive appeal (symmetry, equal spacing of treatments, reduced numbers of observations at the highest and lowest doses).

原文English
主出版物標題Tutorials in Biostatistics, Statistical Methods in Clinical Studies
發行者wiley
頁面315-333
頁數19
1
ISBN(電子)9780470023679
ISBN(列印)0470023651, 9780470023655
DOIs
出版狀態Published - 2005 8月 24

All Science Journal Classification (ASJC) codes

  • 一般數學

指紋

深入研究「Design: Designing Studies for Dose Response」主題。共同形成了獨特的指紋。

引用此