TY - CHAP
T1 - Design
T2 - Designing Studies for Dose Response
AU - Wong, Weng K.
AU - Lachenbruch, Peter A.
N1 - Publisher Copyright:
© 2004 John Wiley & Sons Ltd. All Rights Reserved.
PY - 2005/8/24
Y1 - 2005/8/24
N2 - 'Dose response' refers to the regression of a response on a stimulus. We review a number of options for dose-response designs, and compare various designs which may be used in practice. We start with two group designs. Next, we introduce basic optimal approximate design theory for simple linear and quadratic regression illustrating different criteria of optimality and their effect on the allocation of the levels of the dose. Then we obtain the efficiencies of these optimal approximate designs and some simple designs which have intuitive appeal (symmetry, equal spacing of treatments, reduced numbers of observations at the highest and lowest doses).
AB - 'Dose response' refers to the regression of a response on a stimulus. We review a number of options for dose-response designs, and compare various designs which may be used in practice. We start with two group designs. Next, we introduce basic optimal approximate design theory for simple linear and quadratic regression illustrating different criteria of optimality and their effect on the allocation of the levels of the dose. Then we obtain the efficiencies of these optimal approximate designs and some simple designs which have intuitive appeal (symmetry, equal spacing of treatments, reduced numbers of observations at the highest and lowest doses).
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U2 - 10.1002/0470023678.ch3a
DO - 10.1002/0470023678.ch3a
M3 - Chapter
AN - SCOPUS:84954580072
SN - 0470023651
SN - 9780470023655
VL - 1
SP - 315
EP - 333
BT - Tutorials in Biostatistics, Statistical Methods in Clinical Studies
PB - wiley
ER -