Design of a signal processing circuit for quartz crystal microbalance biosensors

Shih Chang Chang, I. Jen Chao, Bin Da Liu, Chun Yueh Huang, Mei Hwa Lee, Hung Yin Lin

研究成果: Conference contribution

2 引文 斯高帕斯(Scopus)

摘要

In this paper, we design a signal processing circuit for quartz crystal microbalance (QCM) biosensors. The proposed signal processing circuit, which consists of two oscillators, a mixer, a low-pass filter, can be used to measure small amount of QCM biosensors' frequency variation at a fundamental resonance frequency. Based on the principle of heterodyne technique, the QCM biosensors' frequency variation can be converted into the low frequency composition by a second-order low-pass filter. The output of the low-pass filter is digitized to a stream of digital pulses by a simple digital buffer which represents the corresponding QCM biosensor's frequency variation. The proposed signal processing circuit is implemented by 0.35-μm CMOS technology, and the chip layout area is 1060 mm 2. In the proposed circuit, the maximum range of the detectable frequency variation is 26 kHz under the resolution of 0.5 Hz. In system verification, the proposed signal processing circuit chip is successfully applied in the signal processing of α-Amylase QCM biosensors to detect the change of low concentration biomolecular.

原文English
主出版物標題Proceedings - 2011 IEEE 9th International Conference on ASIC, ASICON 2011
頁面180-183
頁數4
DOIs
出版狀態Published - 2011 十二月 1
事件2011 IEEE 9th International Conference on ASIC, ASICON 2011 - Xiamen, China
持續時間: 2011 十月 252011 十月 28

出版系列

名字Proceedings of International Conference on ASIC
ISSN(列印)2162-7541
ISSN(電子)2162-755X

Other

Other2011 IEEE 9th International Conference on ASIC, ASICON 2011
國家/地區China
城市Xiamen
期間11-10-2511-10-28

All Science Journal Classification (ASJC) codes

  • 硬體和架構
  • 電氣與電子工程

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