Designing a molecularly imprinted polymer as an artificial receptor for the specific recognition of creatinine in serums

Ryh Yaw Hsieh, Hsuan Ang Tsai, Mei-Jywan Syu

研究成果: Article同行評審

41 引文 斯高帕斯(Scopus)

摘要

In this study, molecularly imprinted polymers (MIP) synthesized from two different functional monomers, β-cyclodextrin (β-CD) and 4-vinylpyridine (4-Vpy), were prepared. The crosslinkers used for these two monomers were epichlorohydrin (EPI) and divinylbenzene (DVB), respectively. It was attempted to adsorb the target molecule, creatinine, from its mixture solutions. A proper molar ratio of monomer/crosslinker for the preparation of the imprinted poly(β-CD) was 1:10. Between both polymers mentioned above, the affinity of the imprinted poly(4-Vpy-co-DVB) towards creatinine was comparably superior. The imprinted poly(4-Vpy-co-DVB) for creatinine could reach a specific binding ratio of 3.11. The imprinted poly(4-Vpy-co-DVB) was further utilized to bind creatinine from human serum samples. The binding capacity of the imprinted poly(4-Vpy-co-DVB) for creatinine from the serum samples was plotted against the creatinine concentration. From the correlation, the feasibility of the imprinted poly(4-Vpy-co-DVB) thus prepared for the target analyte, creatinine, was experimentally confirmed.

原文English
頁(從 - 到)2083-2089
頁數7
期刊Biomaterials
27
發行號9
DOIs
出版狀態Published - 2006 三月 1

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 陶瓷和複合材料
  • 生物物理學
  • 生物材料
  • 材料力學

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