Game-based learning becomes a critical issue in the e-learning field. Many instructors want to make their students can do the studying with fun and their interest activities. For this reason, this paper designs an interactive RFID learning system for improving learners' motivation and performance by adopting game-based learning. There are several advantages for using this RFID learning system while learners behave well, such as learners will not feel they are engaging in a traditional learning environment when playing the RFID learning system. The purpose of this research was to develop an interactive RFID learning device and competitive learning environment for enhancing students' learning motivation and number sense in mathematics subject. The research is to investigate whether and how this RFID learning system can be developed to help users learn mathematics with enjoyment. This study considers ideas in game design, motivation issues, and mathematics learning to develop a strategy to engage users with the interactive RFID system. In this research, the learners can do the synchronic learning with other classmates outside of the classroom. Moreover, instructors can evaluate the individual's learning levels in mathematics in this research by analyzing the database of the game-based RFID learning system.