Detection of early cognitive impairment using AD8 in a young patient with stroke with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome: A case report

I. Chieh Hsieh, Ta Shen Kuan, Pei Chun Hsieh, Shu Min Chen, Wei Jang Yen, Wen Chen Chang, I. Ling Lin, Yu Ching Lin

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome is a hereditary disease resulting from NOTCH3 gene mutation. The clinical presentations include migraine, recurrent stroke, and cognitive impairment. The severity of cognitive impairment varies in different stages, and early recognition poses a challenge. A 47-year-old lady presented with chronic migraine and sudden onset of hemiparesis. Magnetic resonance imaging revealed compatible findings of CADASIL, which was confirmed by mutation analysis of NOTCH3 gene. Early cognitive impairment was detected by her score of 3 in Ascertain Dementia 8 (AD8) questionnaire and confirmed by detailed neuropsychological assessments. After 21 months of follow-up, deterioration in her cognition and ability to perform instrumental activities of daily living were significant with a follow-up AD8 score of 7. Ascertain Dementia 8 questionnaire is an easy and valid screening tool for early cognitive impairment in patients with CADASIL syndrome.

原文English
頁(從 - 到)133-137
頁數5
期刊American Journal of Alzheimer's Disease and other Dementias
29
發行號2
DOIs
出版狀態Published - 2014 3月

All Science Journal Classification (ASJC) codes

  • 老年病學和老年學
  • 精神病學和心理健康
  • 臨床心理學
  • 一般神經科學

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