Detection of hormone-like and genotoxic activities in indoor dust from Taiwan using a battery of in vitro bioassays

Pei Hsin Chou, Chen Hua Lee, Fung Chi Ko, You Ji Lin, Masanobu Kawanishi, Takashi Yagi, I. Chia Li

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

Indoor dust serves as a potential sink for various synthetic chemicals used in our daily lives, while exposure to these anthropogenic contaminants via dust contact, ingestion, or inhalation may pose potential threats to human health. In this study, in vitro biological assays were used to investigate the endocrine disrupting activity and genotoxicity in dust samples collected from a university located in southern Taiwan. Contents of polycyclic aromatic hydrocarbons (PAHs) in indoor dust were also analysed by gas chromatography mass spectrometry. Our results showed that significant aryl hydrocarbon receptor (AhR) agonist, antiandrogenic, antithyroid hormonal, and genotoxic activities were found in dust samples. In particular, high AhR agonist activities were found in indoor dust collected from computer room and laboratory (16112 and 9686 ng benzo(a)pyrene equivalent/g dust dry weight), whereas AhR agonistic PAHs were responsible for only a small percentage of the bioassay-derived activities. Higher antiandrogenic and genotoxic activities were found in indoor dust from office and classroom, respectively, suggesting that contaminants varied in different indoor dust samples. After fractionating by high performance liquid chromatography, AhR agonist activities were detected in several fractions of indoor dust from computer room and laboratory, indicating the presence of unknown AhR agonist contaminants in these indoor dust samples. Further isolation and identification of novel AhR agonistic and antiandrogenic contaminants is necessary to protect the environment and human health.

原文English
頁(從 - 到)1412-1421
頁數10
期刊Aerosol and Air Quality Research
15
發行號4
DOIs
出版狀態Published - 2015 8月 3

All Science Journal Classification (ASJC) codes

  • 環境化學
  • 污染

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