Development and validation of a nanometer manipulation and measurement system for biomechanical testing of single macro-molecules

Zong Ping Luo, Kai Nan An

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

A biomechanical testing system for single macro-molecules has been developed using optical tweezers. To achieve nanometer manipulation and measurement, a piezo-stage and an interferometer were adopted. A systematic calibration was then performed on the displacement resolution. The piezo- stage has a noise level around 1 nm standard deviation, and the interferometer has a noise level of less than 5 nm standard deviation. The results revealed that the system has a nanometer resolution which is sufficient for the measurement of deformation and stiffness of single macro- molecules.

原文English
頁(從 - 到)1075-1079
頁數5
期刊Journal of Biomechanics
31
發行號11
DOIs
出版狀態Published - 1998 十一月

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 骨科和運動醫學
  • 生物醫學工程
  • 復健

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