TY - JOUR
T1 - Development and Validation of the Chinese Version Non-Nutritive Sweetener Food Frequency Questionnaire with Urinary Biomarker in Children and Adolescents
AU - Chu, Ying Yueh
AU - Chen, Yue Hwa
AU - Hsieh, Rong Hong
AU - Hsia, Shih Min
AU - Wu, Hung Tsung
AU - Chen, Yang Ching
N1 - Funding Information:
Acknowledgements: The authors would like to acknowledge the technical support provided by Core Facility at Taipei Medical University. Financial support: This work was supported by the Taiwan Ministry of Science and Technology [109-2314-B-038-056 and MOST 109-2314-B-038-057]. Authorship: Prof. Y.-Y.C. contributed to cohort data collection, interpretation of data and writing. Prof. Y.-H.C. reviewed the study design, interpreted the data and assisted in sample analytics. Prof. R.-H.H. contributed to the interpretation of data. Prof. S.-M.H. and H.-T.W. contributed to questionnaire development. Prof. Y.-C.C. contributed to cohort data collection and statistical analysis, reviewed the study design and supervised the study. Ethics of human subject participation: The current study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved by the Institutional Review Board at Taipei Medical University (N201911016). Required information and materials related to the study had been explained and well understood by participants before participants or their legal representatives provided written informed consent
Publisher Copyright:
© The Authors 2022.
PY - 2022
Y1 - 2022
N2 - Objective: The purpose of this study was to develop a validated food frequency questionnaire (FFQ) to evaluate the intake of non-nutritive sweeteners (NNSs) in child and adolescent Asian populations. Design: Intensive and overall market research was performed to create the applicable NNS-FFQ with 13 food categories and 305 items. Six intense sweeteners, including acesulfame potassium, aspartame, sucralose, glycyrrhizin, steviol glycosides and sorbitol, were investigated. The validity and reproducibility of the NNS-FFQ were evaluated. The validity was further assessed by examining the consistency of reported NNS intake compared with urinary biomarkers using Cohen's κ analysis. Settings: This work was considered to be relevant in Asian societies. Participants: One hundred and two children and adolescents recruited from several clinics were invited to participate in this study. Results: High content validity indices and high content validity ratio levels were revealed for each sweetener and food category. Reproducibility among subjects was satisfactory. Significant moderate correlations between estimated steviol glycoside/sucralose consumption and sensitive urinary biomarker levels were demonstrated (κ values were 0.59 and 0.45 for steviol glycosides and sucralose, respectively), indicating that the NNS-FFQ can be used to assess an individual's NNS intake. The dietary intense sweetener consumption pattern evaluated in this measurement was similar to those observed in other Asian countries but differed from those observed in Western populations with respect to types and amounts of NNSs. Conclusions: This validated NNS-FFQ can be an applicable and useful tool to evaluate NNS intake in future epidemiological and clinical studies.
AB - Objective: The purpose of this study was to develop a validated food frequency questionnaire (FFQ) to evaluate the intake of non-nutritive sweeteners (NNSs) in child and adolescent Asian populations. Design: Intensive and overall market research was performed to create the applicable NNS-FFQ with 13 food categories and 305 items. Six intense sweeteners, including acesulfame potassium, aspartame, sucralose, glycyrrhizin, steviol glycosides and sorbitol, were investigated. The validity and reproducibility of the NNS-FFQ were evaluated. The validity was further assessed by examining the consistency of reported NNS intake compared with urinary biomarkers using Cohen's κ analysis. Settings: This work was considered to be relevant in Asian societies. Participants: One hundred and two children and adolescents recruited from several clinics were invited to participate in this study. Results: High content validity indices and high content validity ratio levels were revealed for each sweetener and food category. Reproducibility among subjects was satisfactory. Significant moderate correlations between estimated steviol glycoside/sucralose consumption and sensitive urinary biomarker levels were demonstrated (κ values were 0.59 and 0.45 for steviol glycosides and sucralose, respectively), indicating that the NNS-FFQ can be used to assess an individual's NNS intake. The dietary intense sweetener consumption pattern evaluated in this measurement was similar to those observed in other Asian countries but differed from those observed in Western populations with respect to types and amounts of NNSs. Conclusions: This validated NNS-FFQ can be an applicable and useful tool to evaluate NNS intake in future epidemiological and clinical studies.
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U2 - 10.1017/S136898002200088X
DO - 10.1017/S136898002200088X
M3 - Article
AN - SCOPUS:85129031007
SN - 1368-9800
JO - Public Health Nutrition
JF - Public Health Nutrition
ER -