Development of a neurodegenerative disease gait classification algorithm using multiscale sample entropy and machine learning classifiers

Quoc Duy Nam Nguyen, An Bang Liu, Che Wei Lin

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

The prevalence of neurodegenerative diseases (NDD) has grown rapidly in recent years and NDD screening receives much attention. NDD could cause gait abnormalities so that to screen NDD using gait signal is feasible. The research aim of this study is to develop an NDD classification algorithm via gait force (GF) using multiscale sample entropy (MSE) and machine learning models. The Physionet NDD gait database is utilized to validate the proposed algorithm. In the preprocessing stage of the proposed algorithm, new signals were generated by taking one and two times of differential on GF and are divided into various time windows (10/20/30/60-sec). In feature extraction, the GF signal is used to calculate statistical and MSE values. Owing to the imbalanced nature of the Physionet NDD gait database, the synthetic minority oversampling technique (SMOTE) was used to rebalance data of each class. Support vector machine (SVM) and k-nearest neighbors (KNN) were used as the classifiers. The best classification accuracies for the healthy controls (HC) vs. Parkinson’s disease (PD), HC vs. Huntington’s disease (HD), HC vs. amyotrophic lateral sclerosis (ALS), PD vs. HD, PD vs. ALS, HD vs. ALS, HC vs. PD vs. HD vs. ALS, were 99.90%, 99.80%, 100%, 99.75%, 99.90%, 99.55%, and 99.68% under 10-sec time window with KNN. This study successfully developed an NDD gait classification based on MSE and machine learning classifiers.

原文English
文章編號1340
頁(從 - 到)1-1818
頁數1818
期刊Entropy
22
發行號12
DOIs
出版狀態Published - 2020 十二月

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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