TY - GEN
T1 - Development of near-infrared diffuse correlation spectroscopy for noninvasive monitoring of cerebral blood flow
AU - Huang, I. Tseng
AU - Wu, Kuan Chen
AU - Chen, Jia Jin
N1 - Funding Information:
This work is supported by the National Cheng Kung University under grant number MoST 104-2314-B-006-007-MY3. We thank J Chen and J Wu for helpful comments and discussions.
Funding Information:
Acknowledgements This work is supported by the National Cheng Kung University under grant number MoST 104-2314-B-006-007-MY3. We thank J Chen and J Wu for helpful comments and discussions.
Publisher Copyright:
© 2018, Springer Science+Business Media Singapore.
PY - 2018
Y1 - 2018
N2 - Cerebral blood flow (CBF) is a critical physiological process because it controls the oxygen supply, metabolic consumption, and byproduct clearance in the brain. However, a non-invasive method for long-term CBF monitoring is lacking. In recent years, NIR light has been used to monitor brain activities and cerebral blood flow based on DCS technique because it is able to penetrates human skull. The aim of this study was to develop a near infrared (NIR) Diffuse correlation spectroscopy (DCS) system for CBF monitoring. NIR laser at wavelength of 785 nm with properties of continuous wave and long coherence length (>10 m) was emitted into tissue. Single photons scattered by the red blood cells (RBCs) inside the cerebrovascular, were picked up. The auto-correlation function of the optical signal was calculated by the correlator downstream optical-detector. The developed NIR-DCS was first tested on a phantom in which the particle vibration was changed to simulate the changes in blood flow. Then the system was further tested on rats suffered with hypercapnia, normoxia and hyperoxia to measure the changes in CBF. The rats were connected to the ventilator through two plastic tubes—one for inhalation, the other for exhalation. The content of the exhaled gas was analyzed, and the real-time partial pressure of CO2 and the current end tidal CO2 (EtCO2) are measured. The results showed that hyperoxia increased blood flow due to changes in vascular wall tension. The outcome from this study supported DCS as a novel noninvasive method to measure CBF.
AB - Cerebral blood flow (CBF) is a critical physiological process because it controls the oxygen supply, metabolic consumption, and byproduct clearance in the brain. However, a non-invasive method for long-term CBF monitoring is lacking. In recent years, NIR light has been used to monitor brain activities and cerebral blood flow based on DCS technique because it is able to penetrates human skull. The aim of this study was to develop a near infrared (NIR) Diffuse correlation spectroscopy (DCS) system for CBF monitoring. NIR laser at wavelength of 785 nm with properties of continuous wave and long coherence length (>10 m) was emitted into tissue. Single photons scattered by the red blood cells (RBCs) inside the cerebrovascular, were picked up. The auto-correlation function of the optical signal was calculated by the correlator downstream optical-detector. The developed NIR-DCS was first tested on a phantom in which the particle vibration was changed to simulate the changes in blood flow. Then the system was further tested on rats suffered with hypercapnia, normoxia and hyperoxia to measure the changes in CBF. The rats were connected to the ventilator through two plastic tubes—one for inhalation, the other for exhalation. The content of the exhaled gas was analyzed, and the real-time partial pressure of CO2 and the current end tidal CO2 (EtCO2) are measured. The results showed that hyperoxia increased blood flow due to changes in vascular wall tension. The outcome from this study supported DCS as a novel noninvasive method to measure CBF.
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U2 - 10.1007/978-981-10-7554-4_40
DO - 10.1007/978-981-10-7554-4_40
M3 - Conference contribution
AN - SCOPUS:85038096465
SN - 9789811075537
T3 - IFMBE Proceedings
SP - 231
EP - 234
BT - 2nd International Conference for Innovation in Biomedical Engineering and Life Sciences - ICIBEL 2017 in conjunction with APCMBE 2017
A2 - Usman, Juliana
A2 - Ibrahim, Fatimah
A2 - Ahmad, Mohd Yazed
A2 - Teh, Swe Jyan
A2 - Hamzah, Norhamizan
PB - Springer Verlag
T2 - 2nd International Conference for Innovation in Biomedical Engineering and Life Sciences, ICIBEL 2017, held in conjunction with the 10th Asia Pacific Conference on Medical and Biological Engineering, APCMBE 2017
Y2 - 10 December 2017 through 13 December 2017
ER -