Development of seizure monitoring and control systems for epileptic animal models

研究成果: Conference contribution

摘要

The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by any available therapy. Recently, alternative techniques, such as vagus nerve stimulation and deep brain stimulation have been proposed for open-loop seizure control. However, the efficacy of intermittent stimulation may decrease due to neuron acclimation. A closedloop device is more likely to achieve seizure control than an open-loop seizure controller. The objectives of this study are first to develop various epileptic rat models, second to develop a portable wireless closed-loop seizure controller including online seizure detection and real-time electrical stimulation for seizure elimination, and third to apply the developed seizure controller to the animal models to perform on-line seizure elimination. Three epileptic rat models including Long-Evans rats with spontaneous absence epilepsy, pentylenetetrazol (PTZ)-induced convulsive seizure, and temporal lobe epilepsy (TLE) induced by amygdala kindling were successfully developed. A wireless brain-behavior monitoring system that can acquire electroencephalography (EEG) and accelerometer signals simultaneously was designed and it demonstrates successful observation of kindling process and reduces the wire artifacts of EEG signals during convulsions. A portable seizure controller consists of the neural interface with EEG acquisition and electrical stimulation, and on-chip seizure detection was developed. All of the components have been further integrated in the chip-on-board and system-on-chip platform.

原文English
主出版物標題The 15th International Conference on Biomedical Engineering, ICBME 2013
編輯James Goh
發行者Springer Verlag
頁面452-455
頁數4
ISBN(電子)9783319029122
DOIs
出版狀態Published - 2014 一月 1
事件15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
持續時間: 2013 十二月 42013 十二月 7

出版系列

名字IFMBE Proceedings
43
ISSN(列印)1680-0737

Other

Other15th International Conference on Biomedical Engineering, ICBME 2013
國家Singapore
城市Singapore
期間13-12-0413-12-07

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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