Diabetes, Glycemic Control, and Risk of Infection Morbidity and Mortality: A Cohort Study

Chia Hsuin Chang, Jiun Ling Wang, Li Chiu Wu, Lee Ming Chuang, Hsien Ho Lin

研究成果: Article

1 引文 斯高帕斯(Scopus)

摘要

Objective: Diabetic patients have an elevated risk of infection, but the optimal level of glycemic control with the lowest infection risk remains unclear, especially among the elderly. We aimed to investigate the relation between fasting plasma glucose (FPG) level and risk of infection-related morbidity and mortality. Method: The participants were from a community-based health screening program in northern Taiwan during 2005-2008 (n = 118 645) and were followed up until 2014. Incidence of hospitalization for infection and infection-related death was ascertained from the National Health Insurance Database and National Death Registry. Cox proportional hazards regression modelling was used to estimate the hazard ratio (HR) between FPG and risk of infection. Results: During a median follow-up of 8.1 years, the incidence rate of hospitalization for any infection was 36.33 and 14.26 per 1000 person-years among diabetics and nondiabetics, respectively, in the total study population, but increased to 70.02 and 45.21 per 1000 person-years, respectively, in the elderly. In the Cox regression analysis, the adjusted HR comparing diabetics to nondiabetics was 1.59 (95% confidence interval [CI], 1.52-1.67) for any hospitalization for infection and 1.71 (95% CI, 1.36-2.16) for infection-related mortality. The hazard for infection morbidity and mortality was higher at both extremes (<90 and >200 mg/dl) of FPG. The excess risk associated with FPG ≤ 90 mg/dl was attenuated after controlling for multiple comorbidities. Conclusions: Poor glycemic control (FPG > 200 mg/dl) was associated with a higher risk of infection-related morbidity and mortality, especially in the elderly population where the baseline infection risk was high.

原文English
文章編號ofz358
期刊Open Forum Infectious Diseases
6
發行號10
DOIs
出版狀態Published - 2019 九月 30

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

指紋 深入研究「Diabetes, Glycemic Control, and Risk of Infection Morbidity and Mortality: A Cohort Study」主題。共同形成了獨特的指紋。

  • 引用此