Diagnostic value of B-type natriuretic peptide concentrations in patients with acute myocardial infarction

Dawood Darbar, Neil C. Davidson, Neil Gillespie, Anna Maria J. Choy, Chim C. Lang, Yu Shyr, Graeme P. McNeil, Terence H. Pringle, Allan D. Struthers

研究成果: Article同行評審

120 引文 斯高帕斯(Scopus)

摘要

Although elevations of plasma atrial natriuretic peptide (ANP) concentrations have been shown to have prognostic significance in patients after acute myocardial infarction (AMI), the relation between plasma levels of B-type natriuretic peptide (BNP) and cardiovascular mortality remains unknown. To test the prognostic value of plasma ANP and BNP after AMI, plasma concentrations were measured a mean of 3 days after infarction in 75 patients. During a median fallow-up of 19.7 months, 14 patients (18.4%) died of cardiovascular causes. On univariate analysis, plasma ANP and BNP, Killip class, modified Peel index, left ventricular ejection fraction, and presence of left ventricular failure were all associated with cardiovascular mortality. In contrast, plasma ANP was the only variable that correlated with the development of symptomatic heart failure and hospitalization. For the combined end point of cardiovascular mortality, symptomatic heart failure, and hospitalization, plasma neurohormones were the only variables of predictive value. By stepwise regression analysis, plasma BNP was the only significant independent predictor of cardiovascular mortality (p = 0.001), whereas plasma ANP identified patients at risk of symptomatic heart failure and hospitalization (p = 0.002 and 0.019, respectively). This study indicates that plasma BNP measured after AMI is a powerful neurohormonal predictor of subsequent cardiovascular mortality, whereas plasma ANP correlates better with the development of symptomatic heart failure and hospitalization. Routine measurement of both of these peptides in the period immediately after an AMI may provide a simple means of risk stratification with different information gained from each peptide.

原文English
頁(從 - 到)284-287
頁數4
期刊American Journal of Cardiology
78
發行號3
DOIs
出版狀態Published - 1996 八月 1

All Science Journal Classification (ASJC) codes

  • 心臟病學與心血管醫學

指紋

深入研究「Diagnostic value of B-type natriuretic peptide concentrations in patients with acute myocardial infarction」主題。共同形成了獨特的指紋。

引用此