Dicentric isochromosome X with premature ovarian failure: report of two cases.

M. H. Wu, C. C. Tzeng, P. L. Kuo

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Two cases of dicentric isochromosome X, dic (Xp-), with premature ovarian failure are presented. The karyotype of case 1 is 46,X,dic(X)(qter-->p22::p22-->qter), and of case 2 is 45,X (77.5%)/46,X,dic(X)(qter-->p22::p22-->qter) (22.5%). An abnormal menstrual history including delayed menarche and secondary amenorrhea occurring at under 30 years of age was noted. Hormonal profiles revealed elevated levels of serum gonadotropins and decreased levels of estrogens. Gross appearance did not present an obvious picture of Turner's syndrome, except for short stature, poor development of secondary sexual characteristics and infertility. The possible mechanisms of dicentric isochromosome X are the breakage and reunion between either sister chromatid (isodicentric) or homologous chromosomes (homodicentric) which occur during meiosis of the germ cells in case 1 and mitosis after zygote formation in case 2.

原文English
頁(從 - 到)848-850
頁數3
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
92
發行號9
出版狀態Published - 1993 九月

All Science Journal Classification (ASJC) codes

  • 醫藥 (全部)

指紋

深入研究「Dicentric isochromosome X with premature ovarian failure: report of two cases.」主題。共同形成了獨特的指紋。

引用此