Differences between methicillin-resistant Staphylococcus aureus bacteremic isolates harboring type IV and type v staphylococcal cassette chromosome mec genes based on prior patient healthcare exposure

S. Y. Chen, J. L. Wang, T. H.H. Chen, W. C. Chiang, J. T. Wang, S. C. Chen, S. C. Chang, P. R. Hsueh

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

This observational study enrolled adult patients with bacteremia due to methicillin-resistant Staphylococcus aureus (MRSA) who were treated at the emergency department of a teaching hospital from 2001 to 2007. MRSA isolates with type IV and type V staphylococcal cassette chromosome mec (SCCmec) genes (SCC IV/V-MRSA) were included in the final analysis. Healthcare-associated SCC IV/V-MRSA (HA-SCC IV/V-MRSA) and community-acquired SCC IV/V-MRSA (CA-SCC IV/V-MRSA) were defined as the identification of an SCC IV/V-MRSA isolate from a patient with and without healthcare-associated risk factors, respectively. Thirty-four cases of CA-SCC IV/V-MRSA (20 SCCmec type IV, 14 SCCmec type V) and 81 cases of HA-SCC IV/V-MRSA (59 SCCmec type IV, 22 SCCmec type V) bacteremia were identified. Vascular device-associated infections were a significant infection source in HA-SCC IV/V-MRSA bacteremia cases. SCCmec type IV HA-SCC IV/V-MRSA isolates (3.4%) were significantly less likely to carry the Panton-Valentine leukocidin (PVL) gene than SCCmec type IV CA-SCC IV/V-MRSA isolates (35.0%, p = 0.001). The 90-day cumulative probability of survival was 76% for patients with CA-SCC IV/V-MRSA bacteremia and 66% for patients with HA-SCC IV/V-MRSA bacteremia (p = 0.247, by the Wilcoxon rank-sum test). Significant differences in antimicrobial susceptibility were observed between bacterial isolates from patients with CA-SCC IV/V-MRSA bacteremia and HA-SCC IV/V-MRSA bacteremia.

原文English
頁(從 - 到)1539-1546
頁數8
期刊European Journal of Clinical Microbiology and Infectious Diseases
29
發行號12
DOIs
出版狀態Published - 2010 12月

All Science Journal Classification (ASJC) codes

  • 微生物學(醫學)
  • 傳染性疾病

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