Different types of cell death induced by Enterotoxins

Chiou Feng Lin, Chia Ling Chen, Wei Ching Huang, Yi Lin Cheng, Chia Yuan Hsieh, Chi Yun Wang, Ming Yuan Hong

研究成果: Review article

12 引文 斯高帕斯(Scopus)

摘要

The infection of bacterial organisms generally causes cell death to facilitate microbial invasion and immune escape, both of which are involved in the pathogenesis of infectious diseases. In addition to the intercellular infectious processes, pathogen-produced/secreted enterotoxins (mostly exotoxins) are the major weapons that kill host cells and cause diseases by inducing different types of cell death, particularly apoptosis and necrosis. Blocking these enterotoxins with synthetic drugs and vaccines is important for treating patients with infectious diseases. Studies of enterotoxin-induced apoptotic and necrotic mechanisms have helped us to create efficient strategies to use against these well-characterized cytopathic toxins. In this article, we review the induction of the different types of cell death from various bacterial enterotoxins, such as staphylococcal enterotoxin B, staphylococcal alpha-toxin, Panton-Valentine leukocidin, alpha-hemolysin of Escherichia coli, Shiga toxins, cytotoxic necrotizing factor 1, heat-labile enterotoxins, and the cholera toxin, Vibrio cholerae. In addition, necrosis caused by pore-forming toxins, apoptotic signaling through cross-talk pathways involving mitochondrial damage, endoplasmic reticulum stress, and lysosomal injury is discussed.

原文English
頁(從 - 到)2158-2176
頁數19
期刊Toxins
2
發行號8
DOIs
出版狀態Published - 2010 八月

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

指紋 深入研究「Different types of cell death induced by Enterotoxins」主題。共同形成了獨特的指紋。

  • 引用此

    Lin, C. F., Chen, C. L., Huang, W. C., Cheng, Y. L., Hsieh, C. Y., Wang, C. Y., & Hong, M. Y. (2010). Different types of cell death induced by Enterotoxins. Toxins, 2(8), 2158-2176. https://doi.org/10.3390/toxins2082158