Different types of exercise induce differential effects on neuronal adaptations and memory performance

Tzu Wei Lin, Shean Jen Chen, Tung Yi Huang, Chia Yuan Chang, Jih Ing Chuang, Fong Sen Wu, Yu Min Kuo, Chauying J. Jen

研究成果: Article同行評審

80 引文 斯高帕斯(Scopus)

摘要

Different exercise paradigms show differential effects on various forms of memory. We hypothesize that the differential effects of exercises on memory performance are caused by different neuroplasticity changes in relevant brain regions in response to different exercise trainings. We examined the effects of treadmill running (TR) and wheel running (WR) on the Pavlovian fear conditioning task that assesses learning and memory performance associated with the amygdala (cued conditioning) and both the amygdala and hippocampus (contextual conditioning). The skeletal muscle citrate synthase activity, an indicator of aerobic capacity, was elevated in rats received 4w of TR, but not WR. While both TR and WR elevated the contextual conditional response, only TR facilitated the cued conditional response. Using a single-neuron labeling technique, we found that while both TR and MR enlarged the dendritic field and increased the spine density in hippocampal CA3 neurons, only TR showed these effects in basolateral amygdalar neurons. Moreover, both types of exercise upregulated synaptic proteins (i.e. TrkB and SNAP-25) in the hippocampus; however only TR showed similar effects in the amygdala. Injection of K252a, a TrkB kinase inhibitor, in the dorsal hippocampus or basolateral amygdala abolished the exercise-facilitated contextual or cued fear learning and memory performance, respectively, regardless of the types of exercise. In summary, our results supported that different types of exercise affect the performance of learning and memory via BDNF-TrkB signaling and neuroplasticity in specific brain regions. The brain region-specific neuronal adaptations are possibly induced by various levels of intensity/stress elicited by different types of exercise.

原文English
頁(從 - 到)140-147
頁數8
期刊Neurobiology of Learning and Memory
97
發行號1
DOIs
出版狀態Published - 2012 1月

All Science Journal Classification (ASJC) codes

  • 實驗與認知心理學
  • 認知神經科學
  • 行為神經科學

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