Differential changes in Fos-immunoreactivity at the auditory brainstem after chronic injections of salicylate in rats

Jiunn Liang Wu, Tzai Wen Chiu, Paul Wai Fung Poon

研究成果: Article同行評審

21 引文 斯高帕斯(Scopus)

摘要

In human, salicylate-induced tinnitus sometimes occurs a few days after its administration, but the chronic effects of salicylate in animal models are not fully known. In this study, we revealed the distribution of active cells in the rat auditory brainstem by staining an activity marker Fos-protein after multiple daily injections of salicylate. Experimental animals were first given five daily doses of sodium salicylate (250 mg/kg, i.p.). On day 6 they were placed inside a sound room for 8 h before sacrifice. Immunohistochemistry showed a significant increase in the number of Fos-positive cells at the inferior colliculus (IC), particularly its central division. At the cochlear nucleus (CN), only a few Fos-stains were found at the dorsal nucleus while no Fos-stain appeared at the ventral nucleus. The scarcity of Fos-stains at the CN reflected more a lack of external sound inputs than an adaptation in Fos-expression. Since Fos-stains in CN could still be induced on day 6 following brief tonal stimulation. Results are consistent with the hypothesis that salicylate-induced tinnitus is a phantom sound perception related to overactivity of cells at the IC.

原文English
頁(從 - 到)80-93
頁數14
期刊Hearing Research
176
發行號1-2
DOIs
出版狀態Published - 2003 二月

All Science Journal Classification (ASJC) codes

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