Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Yu Ting Tsao, Yao Hung Tsai, Wan Ting Liao, Ching Ju Shen, Ching Fen Shen, Chao Min Cheng

研究成果: Review article同行評審

摘要

Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indications for antibiotic treatment. This article reviews potential protein biomarkers and host-derived gene expression signatures for differentiating between bacterial and viral infections in children, and focuses on emerging multiplex POCT devices for the simultaneous detection of sets of protein biomarkers or streamlined gene expression signatures that may provide rapid and cost-effective pathogen-discriminating tools.

原文English
頁(從 - 到)1118-1132
頁數15
期刊Trends in Molecular Medicine
26
發行號12
DOIs
出版狀態Published - 2020 十二月

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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