Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat

Yu Wen Chen, Jann Inn Tzeng, Ting Yun Chen, Jhi Joung Wang, Yu Chung Chen, Ching Hsia Hung

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)


Although diphenhydramine has been shown to produce longer duration of spinal block than lidocaine, few studies disclose its skin infiltrative anesthesia when compared with a long-lasting local anesthetic, bupivacaine. The purpose of this study was to investigate whether diphenhydramine elicited cutaneous analgesia in comparison with bupivacaine. After inhibition of cutaneous trunci muscle reflex via subcutaneous injection of drugs in rats, we examined the local anesthetic effect of diphenhydramine and bupivacaine as infiltrative cutaneous analgesia in a dose-dependent fashion. We showed that diphenhydramine, as well as bupivacaine displayed a dose-dependent cutaneous analgesia in response to dorsal cutaneous noxious stimuli. The relative potency (50% effective dose) was bupivacaine (0.023 [0.013-0.035]%) > diphenhydramine (0.078 [0.068-0.091]%; P < 0.001). On an equipotent basis, diphenhydramine had a similar duration of action to bupivacaine. Neither local injection of saline nor intraperitoneal administration of a large dose of diphenhydramine or bupivacaine produced cutaneous analgesia (data not shown). We conclude that diphenhydramine is less potent than bupivacaine at producing cutaneous analgesia. At equipotent doses for infiltrative cutaneous analgesia, the duration of action of diphenhydramine is equal to that of bupivacaine.

頁(從 - 到)439-444
期刊Fundamental and Clinical Pharmacology
出版狀態Published - 2014 8月

All Science Journal Classification (ASJC) codes

  • 藥理
  • 藥學(醫學)


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